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Research Paper Details

Nükhet Cavusoglu, Caroline Delattre, Mark Donovan, Sylvie Bourassa, Arnaud Droit, Charles El Rawadi, Roland Jourdain, Dominique Bernard
64 articles
10.1007/s00403-016-1681-4
Paper Abstract

The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological functions provided new insights into the affected metabolic pathways of a dandruff scalp. Dandruff scalp showed (1) profound changes in the expression and maturation of structural and epidermal differentiation related proteins, that are responsible for the integrity of the skin, (2) altered relevant factors that regulate skin hydration, and (3) an imbalanced physiological protease-protease inhibitor ratio. Stratum corneum proteins with antimicrobial activity, mainly those derived from sweat and sebaceous glands were also found modified. Comparing our data with those reported for atopic dermatitis revealed that about 50 % of the differentially expressed proteins in the superficial layers of the stratum corneum from dandruff and atopic dermatitis are identical.

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After being affected by seborrheic dermatitis, I have made it my goal to gather and organize all the information that has helped me in my journey.

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